On functional and structural heterogeneity of VIM-type metallo-β-lactamases
نویسندگان
چکیده
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منابع مشابه
Imipenem-resistant Pseudomonas aeruginosa strains carry vim-type metallo-beta-lactamases isolated from intensive care unit, Shahid Beheshti Hospital, North of Iran
Background: Pseudomonas aeruginosa is the causing agent of many hospital infections and metallo-beta-lactamases (MBL) are being reported with increasing frequency. The aim of this study was to determine the frequency of metallo-&beta-lactamases (MBL) and VIM-1 gene in multidrug-resistant strains of P. aeruginosa isolates and to compare the methods of phenotypic and molecular detection. Materia...
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2. Pournaras S, Tsakris A, Maniati M, Tzouvelekis LS, Maniatis AN. Novel variant (bla(VIM-4)) of the metallo-β-lactamase gene bla(VIM-1) in a clinical strain of Pseudomonas aeruginosa. Antimicrob Agents Chemother 2002;46:4026–8. 3. Toleman MA, Rolston K, Jones RN, Walsh TR. Molecular characterization of VIM-4, a novel metallo-β-lactamase isolated from Texas: report from the CANCER surveillance ...
متن کاملEvolution of Metallo-β-lactamases: Trends Revealed by Natural Diversity and in vitro Evolution
The production of β-lactamase enzymes is one of the most distributed resistance mechanisms towards β-lactam antibiotics. Metallo-β-lactamases constitute a worrisome group of these kinds of enzymes, since they present a broad spectrum profile, being able to hydrolyze not only penicillins, but also the latest generation of cephalosporins and carbapenems, which constitute at present the last resou...
متن کاملفراوانی اینتگرون‌های کلاس I و II در ایزوله‌های بالینی سودوموناس آئروژینوزا مولد متالوبتالاکتاماز
Background and Objective: Pseudomonas aeruginosa is an opportunistic nosocomial pathogen. Evidence suggests that the incidence of enzyme-producing strains of Pseudomonas aeruginosa Metalo Beta Lactamases (MBL) is a major problem in the treatment of infections caused by this organism. The aim of this study was to investigate the frequency of class I and II integrons among metalobetalactamase pro...
متن کاملStructural and biochemical characterization of VIM-26 shows that Leu224 has implications for the substrate specificity of VIM metallo-β-lactamases.
During the last decades antimicrobial resistance has become a global health problem. Metallo-β-lactamases (MBLs) which are broad-spectrum β-lactamases that inactivate virtually all β-lactams including carbapenems, are contributing to this health problem. In this study a novel MBL variant, termed VIM-26, identified in a Klebsiella pneumoniae isolate was studied. VIM-26 belongs to the Verona inte...
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تاریخ انتشار 2002